Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-347-8
CAS number: 105-95-3
no other information
In a sub-chronic toxicity study performed
according to the OECD test guideline No. 408 and in compliance with GLP,
ST 11 C 91 diluted in carboxymethylcellulose was administered by gavage
to Sprague-Dawley Crl:CD®BR rats (15/sex/group) at 50, 250 or 1000 mg/kg
bw/day for 90 days A control group received vehicle alone at the same
volume-dosage (5 mL/kg bw/day). Control and high dose group contained an
additional 10 rats/sex/group for evaluation of recovery from any test
substance-related effects, following a 28-day recovery period.
There were no treatment-related deaths
during the study. Two males treated with 1000 mg/kg bw/day were found
dead during the treatment period one each on Days 34 and 85 almost
certainly following a mal-dose. A 250 mg/kg bw/day female was killed in
extremis on Day 49 after a large mass developed around its abdominal
No clinically observable signs of toxicity
were detected during the study. No adverse effect on bodyweight
development, on dietary intake, on water consumption was detected during
the study. No treatment-related effects were observed during
ophthalmoscopic examination. Haematology, clinical chemistry and
urinalysis were normal. At necropsy, no treatment-related macroscopic or
microscopic lesions were noticed, organ weight were within normal
Based on these observations, the "No
Observed Effect level" (NOEL) was considered to be 1000 mg/kg bw/day. St
11 C 91 is not classified for damage to organs through prolonged oral
dose repeated exposure according to the criteria of the Annex VI of the
Regulation (EC) No 1272/2008 (CLP) and of the Directive 67/548/EEC.
This study is considered as acceptable and
satisfies the requirement for repeated dose toxicity endpoint.
The read-across is considered appropriate
and scientifically justified based on the structural and
physico-chemical similarity and the common toxicological profiles of the
two substances (see §Toxicokinetics for read-across justification).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again