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EC number: 203-347-8
CAS number: 105-95-3
Weight of Evidence approach; geometric means between the two results (experimental and QSAR results):- EC50 = 3.39 mg/L- EC10/NOEC = 2.10 mg/L
Due to the total loss of substance observed
in the experimental study (EU Method C.3 with GLP statement) and the
poor quality of the description of the analytical method, the algae
study is considered as weak and it was preferred to use a weight of
evidence approach with a QSAR (ECOSAR) estimation to provide a more
robust assessment of the toxicity of the substance to algae.
algae toxicity study, performed according to EU Method C3 with GLP
statement, the cultures of Desmodesmus subspicatus were exposed
to the substance at nominal concentrations of 2.0, 2.8, 4.0, 5.6, 8.0,
11.3, 16.0 mg/L under static conditions. Due to the
total loss of this relatively low volatile substance (<LOQ) observed at
the end of this study and the uncertainty as to the reason for this, the
endpoint values were recalculated with ToxRat Professional v2.10 using
the initial measured concentrations. The
recalculated 72h-ErC10 and 72h-ErC50 values were determined to be 10.35
mg/L (95% CL: 10.29 - 10.40 mg/L) and 14.58 mg/L (95% CL: 14.54 - 14.62
In addition, toxicity to green algae was
estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The estimation 96h-EC50 was 0.788 mg/L and the estimated NOEC was 0.426
mg/L (esters class), calculated from a measured log Kow value (4.3) and
To obtain more reliable acute and chronic
toxicity values, geometric means between these two results were
determined. The EC50 and EC10/NOEC values were determined to be 3.39
mg/L and 2.10 mg/L, respectively.
Further investigation is ongoing on this
difficult substance in order to determine whether instability or
analytical issues account for the rapid loss observed under
ecotoxicological test conditions.
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