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EC number: 203-347-8
CAS number: 105-95-3
In a repeat-dose dermal toxicity
study, the test material was applied to the shaved and abraded skin of 6
New Zealand White rabbits/sex/dose at dose levels of 0, 30, 70 or 700
mg/kg bw/day, during a 20-day period.
One rabbit at the 700 mg/kg bw/d
dosage level died on the 21st day of the study.
Dermal irritation noted for all
rabbits included intradermal haemorrhaging, blanching, necrosis and
sloughing of the dead tissues.
The following signs were noted for all
rabbits and were generally slight to moderate and occasionally marked
for rabbits at the 30 mg/kg bw/d dosage level and moderate to marked for
rabbits at the 70 and 700 mg/kg bw/d dosage levels: erythema, edema,
desquamation, coriaceousness and fissuring.
Serum cholesterol values for most of
the rabbits at the 700 mg/kg bw/d dosage level were higher than those of
Under the test conditions, the
LOAEL is 30 mg/kg bw/d based on local effects on the skin.
This study does not meet important
criteria of today's standard methods: the test site was abraded and an
occluded dressing was not used. Therefore it was not considered reliable
for the purpose of hazard evaluation.
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