Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-778-7
CAS number: 2896-70-0
In vivo data reports mild-moderate irritation after extended exposure periods which appear to be reversible. Comparisons with similar molecules reported in the literature conclude the substance to be non-irritating.
The cutaneous reaction to various
nitroxides has been reviewed by Fuchs (2000) in Toxicology of the Human
Environment, the Critical Role of Free Radicals, Ed. Christopher J
Rhodes, Taylor & Francis London pages 139-152
This includes the reaction of Tempo and
similar molecules to both animal and human skin. Uniformly
slight or non-irritant properties have been described. In
addition, for Butoxy Tempo the skin irritation potential (Mullaney T,
2006, Report No 1156/038 ) has been shown to be slight (or non-irritant).
The introduction of an additional
substituent at the 4-position was therefore shown not to influence the
irritation overall and thus on structure/function grounds Oxo-Tempo is
considered to be non-irritant.
A GLP study was performed in accordance with OECD guideline 405, to
assess the effect of 2,2,6,6,-tetramethyl-4 -oxopiperindinooxy when
administered to the eye.
A single dose of 0.1 ml of test material was applied
to the right eye of three New Zealand white rabbits. Assessment of the
animals was made at 1 hour, 24, 48 and 72 hours after treatment.
The test material produced a maximum group mean score of 8.7 and was
classified as a mild irritant (Class 4 on a 1 to 8 scale) to the rabbit
eye using a modified Kay and Calandra classification system.
No classification with respect to eye irritancy is required.
cutaneous reaction of various nitroxides was reviewed by Fuchs (2000)
and concluded, based on comparison with similar molecules and structural
information, that 2,2,6,6-tetramethyl-4-oxopiperidinooxy was not
effects were reported in the acute dermal toxicity study (Cerven, D.R
1995). After 24 hours, exposure to a single dose of 2000mg/kg bw two New
Zealand white rabbits showed an average score of 2 for erythema and 1.5
for oedema using the Draize Dermal Scoring codes. Although not fully
reversible in the 14 day observation period, significant reversal was
sighting tests performed with guinea pigs during a skin sensitisation
study (Allen, D.J, 1997), reported mild – moderate irritation after 24
and 48 hours exposure periods with, amongst other concentrations,
undiluted test substance. The effects observed were fully reversible
within the 48 hour observation period.
mild- moderate irritation was observed in the studies, the exposure
periods were far in excess of the 4 hours cited in OECD 404, Acute
Dermal Irritation/Corrosion. It is reasonable to expect that should a
skin irritation study be performed in accordance with OECD 404, the
effects to the skin would be milder than observed in the dermal acute
and skin sensitisation studies reported.
single study is available to determine the effects on the eye.A
GLP study in accordance with OECD guideline 405, applied a single dose
of 0.1 ml of test material to the right eye of three New Zealand white
rabbits. Assessment of the animals was made at 1 hour, 24, 48 and 72
hours after treatment. The test material produced a maximum group mean
score of 8.7 and was classified as a mild irritant (Class 4 on a 1 to 8
scale) to the rabbit eye using a modified Kay and Calandra
conclusion mild irritation to the eye was observed but was not
sufficiently severe to trigger classification.
The criteria for skin irritation/corrosion and eye irritation according
to Regulation (EC) No 1272/2008 are not met. No classification with
respect to skin irritation/corrosion or eye irritation is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again