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EC number: 220-778-7
CAS number: 2896-70-0
The results are summarised in the tables below:
Body weights, dose volume and dermal reactions
Ear tag no/sex
area stained brown
area appeared dry
% rem %remaining – visual estimate of the amount
of material remaining on the skin, gauze and occlusive binding at 24
hours after the binding was removed.
Draize Dermal Scoring Code
Erythema and Eschar Formation:
No erythema 0
Very slight erythema (barely perceptible)
Well defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight 4
eschar formation (injuries in depth).
No edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of area well-defined by 2
Moderate edema 3
(raised approximately 1.0mm)
Severe edema (raised more than 1.0mm, 4
extending beyond the area of exposure)
Animal E1884-M had diarrhea and/or soiling of the anogenital area on
days 8 through 10. Animal E1892-F appeared lethargic on the day of
dosing but returned to normal by day 1.
A GLP study was conducted to assess the effect of 2,2,6,6-tetramethyl-4
-oxopiperindinooxy when applied dermally. Two New
Zealand white rabbits (one, male and one female) were treated with a
single dose of 2000mg/kg/bw of the test substance. After a contact
period of 24 hours the test substance was removed with distilled water.
The animals were observed 1, 2 and 4 hours post dose, once daily for 14
days for toxicity and pharmacological effects and twice daily for
mortality. Body weights were recorded pre-test, weekly
and at termination.
No mortalities were observed during the test period. Instances of
lethargy, diarrhea and soilng of the anogenital area were noted during
the observation period. Bodyweight changes were normal. Dermal
reactions were well defined on day 1, were slight to well defined on day
7 and absent to slight on day 14.
On the basis of the study results the LD50 was defined
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