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EC number: 220-778-7
CAS number: 2896-70-0
The formation of the metabolites of the stable free radical
4-oxo-2,2,6,6-tetramethylpipreridine-N-oxyl (TEMPONE) was examined in
perfused rat livers. The 4-hydroxy derivative (TEMPOL)
and it’s 1,4-dihydroxy derivative were found to be the major
metabolites, in addition to the corresponding hydroxylamine derivative
No re-oxidation of the hydroxyl group in the 4-position was observed.
The secondary amines of the nitroxides were detected during the
analysis, but the mechanism of their formation remains speculative.
Analysis of the perfusion solution was performed by GC and
GC-MS and also ESR, data from both methods of analysis
showed the half –life of TEMPONE in perfused rat livers to be t½=
47 -70 minutes.
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