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EC number: 925-259-5
CAS number: 140921-24-0
The test substance was investigated in the
Salmonella / microsome test for point-muagenic effects in doses up to
5000 µg per plate on four Salmonella typhimurium LT2 mutants. These
comprised the histidine-auxotrophic strains TA 1535, TA 100, TA 1537 and
TA 98. Doses up to and including 200 µg per plate did not cause any
bateriotoxic effects: Total bacteria counts remained unchanged and no inhibition
of growth was observed.
At higher doses, the substance had a
strain-specific bacteriotoxic effect, so that this range could only be
used to a limited extend up to 5000 mg per plate for assessment
purposes. Evidence of mutagenic activity for the test substance was not
seen. No biologically-relevant increase of the mutant count, in
comparision with the negative controls, was observed. Therefore, the
test substance was considered to be non-mutagenic without and with S9
mix in the Salmonella/microsome test. The positive controls sodium
azide, nitrofurantoin, 4-nitro-1,2 -phenylene-diamine and 2
-aminoanthracene had a marked mutagenic effect, as was seen by a
biologically-relevant increase in mutant colonies compared to the
corresponding negative controls.
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