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EC number: 925-259-5
CAS number: 140921-24-0
The treated animals received a single
intraperitoneal administration of either test substance or
cyclophosphamide (positive control). The femoral marrow of groups
treated with test substance was prepared 16,24 and 48 hours after
administration. All negative and positive control animals were sacrified
after 24 hours. The doses of test substance and positive control were 15
and 20 mg/kg bw, respectively. The animals treated with test substance
showed symptoms of toxicity after administration. One of the forty
animals died before the end of the test due to the acute inraperitoneal
toxicity of 15 mg/kg test substance. There was weekly altered ratio
between polychromatic and normochromatic erythrocytes.
The results with the test substance
gave no relevant indications of clastogenic effects after single
intraperitoneal treatment with 15 mg/kg. The known mutagen and
clastogen, cyclophosphamide, had a clear clastogenic effect at an
intraperitoneal dose of 20 mg/kg bw. The number of micronucleated
polychromatic erythrocytes increased to a biologically relevant degree.
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