Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: -
CAS number: -
There were no deaths, no signs of ill health or toxicity and no signs of
local irritation over the treated area during the pre-screen and main
tests. Ear thickness was also unaffected during the pre-screen test.
Wet/greasy fur on the head following each dosing occasion and in some
animals persisting until Day 5 was not attributable to the test
substance itself but was considered to be related to unoccluded dermal
administration of a liquid formulation/vehicle. A clear sticky residue
on the ears on Days 2 to 5 in all animals dosed with 100% w/v was
considered to represent residual test substance, slight hair loss noted
on Day 6 in the pre-screen animals probably resulted from grooming of
the animals to remove the residue.
Bodyweight gain was unaffected by treatment with the test substance.
all concentrations tested, the attained stimulation indices were greater
than the threshold value of 3 at and above which a test substance is
regarded to be a potential skin sensitizer. In addition, a dose-related
increase in stimulation index was evident. Log-linear
the stimulation indices attained at the two lower doses produced an
EC3ex value of 19.5% w/v.
local lymph node assay with mice, the stimulation index (SI) threshold
of ≥ 3.0, indicating a positive sensitisation response, was attained in
all treated groups. The EC3ex value was calculated to be 19.5% w/v. Therefore,
to EU classification rules the
test substance was classified as “Category
1, subcategory 1B” (Warning: May cause an allergic skin reaction; other
(than strong) skin sensitiser) [REGULATION
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again