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EC number: -
CAS number: -
conduct of an in vitro skin corrosion test (OECD 431) was deemed
unnecessary for the following reasons:
1. Absence of any dermal irritation in the local lymph node assay in
mice treated with WS400123 at up to and including 100% w/v,
Non-irritancy of neat WS400123 in the in vitro EPPISKIN skin irritation
study, and of WS400123 formulation in the in vivo skin irritation study.
Absence of relevant eye irritation or corrosion in the in vivo eye
irritation studies with neat WS400123 or WS400123 formulation,
corrosion properties of WS400123 are not to be expected
from its pH value (measured to be 7.64 as part of the in vivo eye
irritation study with neat WS400123).
view of the absence of any relevant effects during the skin and eye
irritation studies with WS400123, the attained results do not
necessitate any classification and labelling regarding skin or eye
irritation according to EU classification rules [REGULATION (EC)
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