Registration Dossier
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EC number: 701-048-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS400123, a complex mixture of components. Low to moderate absorption and systemic availability of WS400123 or components of it after oral or topical administration cannot be entirely discounted, because of its, possibly moderate, partition coefficient value (Log10Pow< 1), low water solubility (2.5 mg/L) and, to some extent, its molecular weight (ca. 300 – 600). An indication of systemic absorption of WS400123 or a small fraction of it after oral administration may be reductions in a number or red blood cell parameters attained in rats after 5 weeks of treatment by oral gavage. Some dermal absorption has been concluded from the sensitization response attained in a Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400123.
Exposure of humans to WS400123 by the inhalation route is unlikely, because of its very low vapour pressure (1 x 10-3Pa at 25°C), its decomposition at high temperature without boiling (above ca. 150°C) and because it is a highly viscous liquid.
All available study results gave no indication regarding the metabolic pathway, distribution or excretion of WS400123. Bioaccumulation was not investigated, but in view of its Log10Pow< +1, WS400123 is not considered to be bioaccumulative.
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