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EC number: -
CAS number: -
The acute oral toxicity
study demonstrated that the LD50 of WS400123 is considerably higher than
the limit dose of 2000 mg/kg b.w.
As detailed in the
justification for data waiving, the conduct of an acute dermal toxicity
study would not have added relevant toxicological hazard information and
adequate protection of human health will be granted anyway, as WS400123
has been classified as a skin sensitizer necessitating whole body
protective precautions during its handling and use.
The conduct of an acute
inhalation toxicity study with WS400123 is not warranted, as the
inhalation exposure of humans to WS400123 is unlikely because of its
very low vapour pressure, its decomposition at high temperature before
boiling and because it is a higly viscous liquid.
acute oral toxicity study, all animals survived a single dose of
WS400123 formulation up to 10.0 mL/kg bw equivalent to neat WS400123 up
to 5385 mg/kg. Therefore, classification of WS400123 for acute oral
toxicity is not required [REGULATION (EC) 1272/2008].
of WS400123 by the dermal route was reasonable, because of the absence
of effects indicative of relevant local irritation or systemic toxicity
(apart from the sensitization response) in the available in vitro skin
and in vivo skin and eye irritation studies and local lymph node assay
with topical administration of neat WS400123 or WS400123 formulation,
for WS400123 the
systemic exposure is likely to be higher by the oral than by the dermal
of WS400123 by the inhalation route was justified, because WS400123 has
a very low vapour pressure, decomposes before boiling and is a highly
viscous liquid, making the inhalation exposure of humans to vapour or
droplet aerosol unlikely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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