Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

A study on skin sensitization is not available for the substance. Such a study does not need to be conducted according to Regulation (EC) No. 1907/2006, 8.5., Column 2, since the substance is classified as "corrosive". However, the database for the structurally similar substance 1,6 -diisocyanatohexane (HDI; CAS 822 -06 -0) indicates a potential for skin sensitization (Classification as skin sens. Cat. 1). Based on read across this is also valid for 1,5 -diisocyanatopentane.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Information on respiratory sensitization is not available for the substance. However, the database for the structurally similar substance 1,6 -diisocyanatohexane (HDI; CAS 822 -06 -0) indicates a potential for respiratory sensitization (Classification as resp. sens. Cat. 1). Based on read across this is also valid for 1,5 -diisocyanatopentane.

Justification for classification or non-classification

According to Regulation (EC) No 1272/2008, Annex I, classification is warranted for skin sensitization as Cat. 1 (H317: May cause an allergic skin reaction). Based on the available data (read across) an allocation into sub-categories for skin sensitization cannot be justified.

According to Regulation (EC) No 1272/2008, Annex I, classification is warranted for respiratory sensitization as Cat. 1 (H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled). Based on the available data (read across) an allocation into sub-categories for respiratory sensitization cannot be justified.