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EC number: 807-040-5
CAS number: 4538-42-5
Mortality during main test:
Under semi-static conditions (24 h renewal), the acute toxicity of the
test substance of POI to
Rare minnow (Gobiocypris rarus) was conducted according to: "The
guidelines for the testing of
chemicals" (HJ/T 153-2004), "The Guidelines for the Testing of
Chemicals, Effects on Biotoc
Systems" (the 2nd edition) (2013); and with reference to Procedure 203
of the "Guidelines for
Testing of Chemicals" of the OECD: "Fish, Acute Toxicity Test" ( 1992).
According to the information provided by sponsor, the test substance is
insoluble and hydrolyzed
in water quickly. Since there is no standard of hydrolyzate, UPLC or GC
cannot be used to
determine the hydrolyzate's concentration in water accurately. While TOC
method can accurately
detect the concentration of the test substance in test water, and
characterize the stability of the test
A range-finding test with several concentrations was performed (1.0,
10.0 and 100 mg/L nominal).
Semi-static conditions (24 h renewal) method was adopted in limit test.
Based on the results of
the range-finding test, the concentration of 100 mg/L was assigned in
limit test. For each test tank
3 L test solution was filled in. 3 replicate was assigned for each
treatment group and control
group, while the initial number of testing fish was 7 for each group.
The test fish were randomly chosen and put in appropriate test solutions
after the temperature has
been adjusted to the required value. This was done in 30 min.
During the test period, the pH values of the control mediums and test
mediums were between
7.79 and 7.89, the Dissolved Oxygen (DO) values varied from 77 % to 95 %
of the air saturation
at the test temperature; the total hardness was in the range of 155 mg
(CaC03)/L to 162 mg
(CaC03)/L; the temperature of the test mediums was maintained in the
range of 23.0 °C to 23.2
°C and all fishes in the control group were normal. With the same
conditions, K2Cr20 7 was used
as the positive control substance, and the resulting 24 h-LCso was 282
During the test period, all fish in the control groups and treated
groups were alive and appeared
normal. The results showed that under valid semi-static conditions (24 h
renewal), the 96 h-LC50
of test substance to fish (Rare minnow, Gobiocypris rarus) was greater
than the nominal
concentration of 100 mg/L (mean measured concentration 93 .9 mg/L),
while the maximum
concentration causing no mortality (96 h-LC0) was equal to the nominal
concentration of I 00
mg/L (mean measured concentration 93.9 mg/L). i.e.:
96 h-LC50 > 100 mg/L (mean measured concentration 93.9 mg/L);
96 h-LC0 = 100 mg/L (mean measured concentration 93.9 mg/L).
The results showed that under valid semi-static conditions (24 h
renewal), the 96 h-LC50 of test substance to fish (Rare minnow,
Gobiocypris rarus) was greater than the nominal concentration of 100
mg/L (mean measured concentration 93.9 mg/L), while the maximum
causing no mortality (96 h-LC0) was equal to the nominal concentration
of 100 mg/L (mean measured concentration 93.9 mg/L). i.e.:
96 h-LCso > 100 mg/L (mean measured concentration 93 .9 mg/L);
96 h-LCo = 100 mg/L (mean measured concentration 93.9 mg/L). (Wu 2017)
The 96h-LC0 for 1,6 -diisocyanatohexane (CAS 822-06-0) which is a
similar substance as Pentane, 1,5 - diisocyanato was
found to be > 82.8 mg/L (Caspers, 2000)
"Should read: > 100 mg/L"
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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