Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 807-040-5
CAS number: 4538-42-5
The substance was assessed for its potential to induce micronuclei in
human lymphocytes in vitro in accordance to OECD Guideline 487. In two
independent experiments the cells were exposed either for 4 hours (pulse
exposure) with or without S9 mix, or for 20 hours (continuous exposure)
without S9 mix. The highest concentration applied (1542.0 µg/mL of the
test item, approx. 10 mM) was chosen with regard to the molecular weight
of the test item and with respect to the current OECD Guideline 487.
In this study, at both treatment intervals, a biologically relevant
cytotoxicity indicated by not evaluable concentrations could be observed
(in the absence of S9 mix at a concentration of 771.0 μg/mL and above,
in the presence of S9 mix at a concentration of 385.5 μg/mL). In both
experiments, in the absence and presence of S9 mix, no biologically
relevant increase in the number of cells carrying micronuclei was
observed. The micronucleus rates of cells after treatment with the test
item (0.35-1.05 %) surpassed the range of the solvent controls
(0.30-0.45 %) as well as the negative controls (0.40- 0.55 %), but were
within the range of the laboratory historical control values for organic
solvents other than EGDE.
The positive controls used (Demecolcin, MMC or CPA) showed distinct
increases in cells with micronuclei.
Thus, the test item was considered to be non-mutagenic in this in vitro
micronucleus test, when tested up to the highest evaluable concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Šajā tīmekļa vietnē tiek izmantoti sīkfaili, lai nodrošinātu Jums vislabāko lietojumu mūsu tīmekļa vietnēs.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again