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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Acute toxicity to fish: The 96h-LC0 for 1,6 -diisocyanatohexane (CAS 822 -06 -0) was found to be >= 82.8 mg/L and the result is related to the arithmetic mean of analytical values (Caspers, 2000). The result relates to 1,6 -diisocyanatohexane (CAS 822 -06 -0) which was used in a read-across approach. 1,6 Diisocyanatohexane is a similar substance as Pentane, 1,5 -diisocyanato- containing an alkyl chain of 6 C-atoms, whereas Pentane, 1,5 –diisocyanato contains 5 C-atoms.

Acute toxicity to daphnia: After 48 hrs no toxic effects against daphnia magna were observed at the limit loading of 100 mg/L under exposure conditions (Spoo-Klöppel, 2016).

Toxicity to freshwater algae: No toxic effects against algae were observed at the limit loading of 100 mg/L after 72 hrs under exposure conditions (Spoo-Klöppel, 2016).

Toxicity to microorganisms: After three hours the test material showed approx. 3 % respiration inhibition of activated sludge at the highest concentration of 1000 mg/L. An EC-50 value of higher than 1000 mg/l and EC-10 value of 856.5 mg/l was determined (by probit analysis) (Spoo-Klöppel, 2016).

All toxicity studies mentioned above are classified as acceptable and satisfy the guideline requirements for the toxicity studies on acute toxicity to aquatic organisms