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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
ANALOGUE APPROACH JUSTIFICATION
See document attached to section "13.2 Other assessment reports"
Cross-reference
Reason / purpose for cross-reference:
read-across source
Reference
Endpoint:
basic toxicokinetics
Type of information:
other: toxikokinetics assessment
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The assessment of the toxicokinetics of HDI is based on experimental toxicokinetic studies in animals and volunteers. In addition, further toxicological data as well as physico-chemical properties of the compound were taken into account.
Justification for type of information:
ANALOGUE APPROACH JUSTIFICATION
See document attached to this endpoint study record
Principles of method if other than guideline:
assessment on toxicokinetics

For an assessment of toxicokinetics read across is performed to HDI (CAS no. 822 -06 -0). For that purpose, the toxicokinetic assessment of HDI, which is based on experimental toxicokinetic studies in animals and volunteers, physico-chemical properties, and further toxicological data, is cited below. Given that the read across is justified, this is favourable to a toxicokinetic assessment solely based on PDI data, since the toxicokinetic database of HDI is much broader than that of PDI.


(For justification of read across see document attached to section 13.2 Other assessment reports.)

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1,5-Diisocyanatopentane
EC Number:
807-040-5
Cas Number:
4538-42-5
Molecular formula:
C7H10N2O2
IUPAC Name:
1,5-Diisocyanatopentane
Test material form:
liquid

Results and discussion

Applicant's summary and conclusion

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