Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The assessment of the toxicokinetics of HDI is based on experimental toxicokinetic studies in animals and volunteers. In addition, further toxicological data as well as physico-chemical properties of the compound were taken into account.
Justification for type of information:
ANALOGUE APPROACH JUSTIFICATION
See document attached to this endpoint study record

Data source

Reference
Reference Type:
other: Toxicokinetics Assessment
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Principles of method if other than guideline:
assessment on toxicokinetics

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

For an assessment of toxicokinetics read across is performed to HDI (CAS no. 822 -06 -0). For that purpose, the toxicokinetic assessment of HDI, which is based on experimental toxicokinetic studies in animals and volunteers, physico-chemical properties, and further toxicological data, is cited below. Given that the read across is justified, this is favourable to a toxicokinetic assessment solely based on PDI data, since the toxicokinetic database of HDI is much broader than that of PDI.

(For justification of read across see document attached to the endpoint summary.)

Applicant's summary and conclusion