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EC number: 807-040-5
CAS number: 4538-42-5
According to OECD TG 437 a substance is identified as inducer of serious
eye damage if the IVIS (in vitro irritation score) value exceeds 55.
In vitro irritancy score:
No potential for serious eye damage was concluded from the study, as the
IVIS was below 55 for the test item.
The test substance was investigated according to OECD TG 437 in the
Bovine Corneal Opacity and Permeability (BCOP) test. This in vitro test
is used to identify chemicals with a potential for serious eye damage.
In this study 750 µL of the unchanged test substance was applied on the
epithelial surface of an extracted bovine cornea. Measurement of corneal
opacity and permeability after a 10-minute exposure time and an
additional 2-hour incubation time revealed an IVIS well below the
cut-off value of 55, that is indicating a classification for serious eye
damage according to OECD TG 437. The positive (1 % sodium hydroxide
solution) and negative (water) controls confirmed the validity of the
Thus, under the conditions of this test no potential for serious eye
damage can be concluded.
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