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EC number: 807-040-5
CAS number: 4538-42-5
According to OECD TG 431 a chemical should be classified as
"corrosive" if the cell viability after a 3-min. treatment with a test
item is decreased by more than 50 %.
control NaCl 0.9 %
In this case the test item was characterized by having a
significant impact on cell viability after the 3 -min. or the 60-min.
An in vitro study according to OECD TG 431 for predicting a non
specific, corrosive potential of a substance was conducted. In that
study undiluted test item was applied topically on a reconstructed human
skin (50 µL; epiCS, CellSystems, Germany). After an exposure period of 3
minutes at room temperature and 60 minutes in an incubator (37 °C, 5 %
CO2, maximum humidity), the cell viability was 13 % and 2 %,
respectively, as measured by a MTT conversion assay. Based on OECD TG
431 the test substance should be therefore classified as corrosive.
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