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EC number: 238-405-1
CAS number: 14433-76-2
The acute dermal toxicity
in rats was determined according to the method recommended in the OECD
Guideline No. 402 "Acute Dermal Toxicity", Feb. 1987, and the
corresponding EEC GuidelineB.3 "Acute Toxicity (Dermal)", 29.12.92.
The study was performed
as a limit test with 10 Wistar rats (five males and five females). The
rats were exposed to a single dermal dose of 5000 mg/kg b.wt. for 24
hours followed by an observation period of 14 days. During the study
clinical signs of reaction to the treatment were recorded daily. Body
weight was recorded once a week. After the two week observation period
the animals were killed and subjected to a gross necropsy examination.
All animals in the main
study survived the treatment and showed very slight signs of toxicity.
Under the experimental
conditions described in this report, the dermal LD50 of the test
substance in rats was found to be above 5000 mg/kg b.wt.
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