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EC number: 238-405-1
CAS number: 14433-76-2
The acute oral toxicity
in rats was determined according to the method recommended in the OECD
Guideline No. 420, "Acute Oral Toxicity - Fixed Dose Method", July 1992
and the corresponding EEC GuidelineB.l bis "Acute Toxicity (Oral)",
The study was initiated
with a sighting study, in which one female rat was given SAT 970 419
(N,N-Dimethyldecan-1 -amide) in a 2000 mg/kg b.wt. dose. Slight signs of
toxicity were observed in this rat. Another female rat was given SAT 970
419 (N,N-Dimethyldecan-1-amide) in a 5000 mg/kg b.wt. dose. This animal
died under severe signs of toxicity on day 2.
On the basis of the
results from the sighting study it was decided to carry out the main
study with one group consisting of five male and five female rats given
a dose of 2000 mg/kg b.wt.
All animals in the main
study survived the treatment and showed slight signs of toxicity
(clinical signs: pinched abdomen, piloerection). Gross
necropsy revealed a gas filled intestine for three animals, distended
vessel of testes in one animal, light margin of liver in two animals.
Under the experimental
conditions described in this report, the oral LD50 of SAT 970 419
(N,N-Dimethyldecan-1-amide) in rats was found to be above 2000 mg/kg
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