Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 238-405-1
CAS number: 14433-76-2
ASSESSMENT AND DISCUSSION:
The test substance as an aerosol proved to have a relatively low acute
inhalative toxicity in the rat up to the maximum tested concentration of
3551 mg/m3 air.
A single 4-hour exposure to 3551 mg/m3 air resulted in relatively
persistent respiratory disorders considered to be causally related to a
primary irritant effect on the respiratory tract. The hypothermia
determined from 586.4 mg/m3 air is considered to be causally related to
the aerosol's local irritant potential.
A study for acute inhalation toxicity was conducted with "confidential
substance name" in accordance with OECD Guideline No. 403.
Therefore 5 SPF-bred Wistar rats were exposed (head/nose only) to 118.5;
586.4; 2007.6 and 3550.7 mg/m3 (analytical determined).
Rats subjected to a concentration of 119 mg/m3 air tolerated the
exposure without signs occurring. Rats exposed to 586 mg/m3 air
exhibited a transient reddening of the nose on the day of exposure and
reduced motility. Rats subjected to the max. tested concentration (3551
mg/m3 air; nebulization of the undiluted test article) exhibited
persistent signs causally linked to an irritation of the respiratory
tract (slower breathing, serous nasal discharge, dyspnea, stridor,
hypothermia). 3551 mg/m3 air was the range at which mortality started
for male rats (1 of 5 died). The results of this study show that the
respirable test article aerosol had a relatively low acute inhalative
toxic effect on the rat. The acute potential hazard of the respiratory
tract is attributed to the potency of the test substance aerosol to act
as a mucosa irritant. LC50 inhalation (aerosol) Rat (exposure: 4 h) >
3551 mg/m3 air
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Šajā tīmekļa vietnē tiek izmantoti sīkfaili, lai nodrošinātu Jums vislabāko lietojumu mūsu tīmekļa vietnēs.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again