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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: PC4180000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 1,5,1951
Reference Type:
review article or handbook
Title:
DPIM: TJK000
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):- Arzneimittel-Forschung. Drug Research. 1 (1951), 5.
Reference Type:
other: Authoritative data base
Title:
GCID: 251789
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):- Arzneimittel-Forschung. Drug Research. Vol. 1, Pg. 5, 1951.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS, SAX & Actor
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material : p,p',p''-tris(dimethylamino)trityl alcohol
- Substance type: Organic
- Molecular formula : C25H31N3O
- Molecular weight : 389.5331

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 other: mg/kg
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 (Oral) for p,p',p''-tris(dimethylamino)trityl alcohol in Mouse is 1000 mg/kg suggests that the substance is toxic by the oral route.
Executive summary:

LD50 (Oral) value of p,p',p''-tris(dimethylamino)trityl alcohol in Mouse is 1000 mg/kg suggests that the substance is toxic by the oral route.