Registration Dossier

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on three hydrolysis studies as-
2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Type:
not specified
Remarks on result:
other: 2. lack of hydrolysable fuctional group
Type:
not specified
Remarks on result:
other: 3. lack of hydrolysable fuctional group
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical is not hydrolysable due to lack of fuctional group.
Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH fromauthoritative database (HSDB). The results of studies are mentioned below:

In first study it was mentined that Aromatic amines are generally resistant to aqueous environmental hydrolysis therefore,test chemical is not expected to hydrolyze in water.

In another study the test chemical is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions Therefore it can be concluded that test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical is not hydrolysable due to lack of fuctional group.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical is not hydrolysable due to lack of fuctional group.

Key value for chemical safety assessment

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH fromauthoritative database (HSDB). The results of studies are mentioned below:

In first study it was mentioned that Aromatic amines are generally resistant to aqueous environmental hydrolysis therefore,test chemical is not expected to hydrolyze in water.

In another study the test chemical is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions Therefore it can be concluded that test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical is not hydrolysable due to lack of fuctional group.