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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Principles of method if other than guideline:
Long term toxicity of test chemical were evaluated on the basis of predicted reproduction inhibition of daphnia magna.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
Common name: Water Flea
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
21 d
Reference substance (positive control):
no
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.293 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
reproduction
Remarks on result:
other: Neutral Organic SAR
Validity criteria fulfilled:
no
Conclusions:
On the basis of no effects observed on Daphnia magna, the NOEC value for the substance is estimated to be 0.293 mg/l for aquatic daphnia magna for 21days of exposure duration.
Executive summary:

Based on the prediction done using ECOSAR version 1.11, the long term toxicity on daphnia was predicted for test substance. On the basis of no effects observed in a flow through freshwater system, the NOEC value for the test substance is estimated to be 0.293 mg/l for daphnia magna for 21 days of exposure. As no effect were observed thus chemical cannot be classify in toxic category

Description of key information

Based on the prediction done using ECOSAR version 1.11, the long term toxicity on daphnia was predicted for test substance. On the basis of no effects observed in a flow through freshwater system, the NOEC value for the test substance is estimated to be 0.293 mg/l for daphnia magna for 21 days of exposure. As no effect were observed thus chemical cannot be classify in toxic category.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.293 mg/L

Additional information

Based on the prediction done using ECOSAR version 1.11, the long term toxicity on daphnia was predicted for test substance. On the basis of no effects observed in a flow through freshwater system, the NOEC value for the test substance is estimated to be 0.293 mg/l for daphnia magna for 21 days of exposure. As no effect were observed thus chemical cannot be classify in toxic category.