Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-218-2 | CAS number: 561-41-1 with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Adsorption / desorption
KOCWIN model of Estimation Programs Interface was used to predict the soil adsorption coefficient i.e Koc value of test chemical. The soil adsorption coefficient i.e Koc value of test chemical was estimated to be 13670 L/kg (log Koc=4.1359) by means of MCI method (at 25°C). This Koc value indicates that the test chemical has a strong sorption to soil and sediment and therefore have negligible to slow migration potential to ground water.
Additional information
Adsorption / desorption
Various predicted data for the target chemical andsupporting weight of evidence studies of its read across chemicalswere reviewed for the adsorption end point which are summarized as below:
In a prediction done using KOCWIN Program of Estimation Programs Interface, the soil adsorption coefficient i.e Koc value of test chemical was predicted. The soil adsorption coefficient i.e Koc value of test chemical was estimated to be 13670 L/kg (log Koc=4.1359) by means of MCI method (at 25°C). This Koc value indicates that the test chemical has a strong sorption to soil and sediment and therefore have negligible to slow migration potential to ground water.
Another predicted data was estimated using Chemspider database (2020) for predicting the adsorption coefficient (Koc) of test chemical. The adsorption coefficient (Koc) of test chemical was estimated to be 767.50 (logKoc = 2.885) at pH 5.5 and 4239.84 (logKoc = 3.627) at pH 7.4, respectively. This Koc value indicates that the test chemical has a moderate to strong sorption to soil and sediment and therefore have negligible to slow migration potential to ground water.
The adsorption coefficient (Koc) for test chemical was predicted by Scifinder database at pH 1-10 and temperature 25 °C. The adsorption coefficient (Koc) of test chemical was estimated to be 1, 2.85, 138, 1430, 2910, 3220, 3250 and 3260 (at 25°C) (logKoc value ranges from 0 to 3.513) at pH 1-3, 4, 5, 6, 7, 8, 9 and 10, respectively. The Koc value (i.e., logKoc = 3.46 at pH 7.0) indicates that the test chemical has a strong sorption to soil and sediment and therefore have negligible to slow migration potential to ground water.
In a supporting weight of evidence study from study report (2019),the adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The solutions of the test substance and reference substances were prepared in appropriate solvents. The sample of test chemical was prepared by adding 10 mg in acetonitrile to prepare 1000 mg/L test solution, sonicated for 1 mins and filtered through 0.22 μm nylon syringe filter. pH of the resulting solution was 7.4. The analysis was performed at constant recommended conditions such as temperature 25°C (solvent: water) ratio 55:45 at the flow rate of 1 mL/min at 210 nm. The reference substances were chosen according to estimated Koc range of the test substance and generalize calibration graph was prepared. Selected reference substances and test chemical were prepared in acetonitrile with concentration of 400 mg/L. Both were analyzed on HPLC considering the similar conditions. After analyzing on above conditions calibration curve of selected reference substances was prepared to obtain log Koc value. The reference substances were p-Toluamide, Aniline, N-methylaniline, 4-Chloroaniline, phenanthrene, Naphthalene, DDT, having Koc value ranging from 1.8 to 2.9. The Log Koc value of test chemical was determined to be 2.787±0.001 dimensionless at 25°C.This log Koc value indicates that the substance has a moderate sorption to soil and sediment and therefore have slow migration potential to ground water.
For the test chemical, the adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals (Experimental study report, 2018). The solutions of the test substance and reference substances were prepared in appropriate solvents. A test chemical solution was prepared by accurately weighing 4 mg of test item and diluted with Methanol up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 8.3. Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k. The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. The reference substances were chosen according to estimated Koc range of the test substance and generalized calibration graph was prepared. The reference substances were Benzamide, 4 -methylaniline(p-Tolouidine), N-methylaniline, Nitrobenzene, 4-Nitrobenzamide, N,Ndimethylbenzamide, N-methylbenzamide, 2 - nitrophenol having Koc value ranging from 1.239 to 2.47. The Log Koc value of test chemical was determined to be 3.055± 0.005 dimensionless at 25°C.This log Koc value indicates that the substance has a moderate sorption to soil and sediment and therefore have slow migration potential to ground water.
On the basis of above results, it can be concluded that the logKoc value of test chemical was evaluated to be ranges from 2.787 to 4.13, respectively, indicating that the test chemical has as a moderate to strong sorption to soil and sediment and therefore have negligible to slow migration potential to ground water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1