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EC number: 201-297-1
CAS number: 80-62-6
Skin irritationHuman dataPatch test study with volunteers: 18/20 showed erythema and dermatitis after exposure to 5% methyl methacrylate in paraffin or olive oil (Nyquist 1958). Although a clear distinction between sensitisation and irritation is difficult and the exposure period is far longer than usual in irritation testing the results suggest that MMA may have the potential for skin irritation in humans.Animal datain vivo, rabbit: low to moderate potential for skin irritation (Sterner 1977; Rohm & Haas 1982)
Eye irritationAnimal datain vivo, rabbit, 0.1 mL, unwashed: no potential for eye irritation (Sterner 1978, Rohm and Haas 1982)Irritation of the respiratory tractHuman dataWorkplace exposure: acute and reversible irritation at concentration levels exceeding 100 ppm (ca. 0.410 mg/L; (Coleman, 1963, Roehm 1994, Muttray et al., 1997, Muttray et al., 2007)
The mean erythema and edema scores of the 24 and 72 h readings of the
scarified skin sites were 0.25 and 0.0, respectively. The slight
erythema were fully reversible within 72 h.
In an acute dermal irritation test acc. to Draize 1959 6 New Zealand
White rabbits were exposed to methyl methacrylate under occlusive
conditions for 24 hours on the shaved skin. Very slight erythema was
observed in one animal which was fully reversible within 72 h.
Screening study with two animals. Only two animals: Effects in one
animal were slight and fully reversibe, in the other animal a strong
irritant response was observed but reversibility was not fully assessed
WoE conclusion based on dermal tox. screening data: Fully reversible
within 3 days at 0.2 mg/kg
2 rabbits received 0.2, 2 or 5 g/kg bw (occluded) for 24h.
Moderate/severe irritation was observed at 24h. Complete recovery
occurred at 0.2 g/kg (dose comparable to irritation guideline) but not
at 2 or 5 g/kg.
Based on screening data with two animals and
4 hours exposure of 0.5 ml of methyl methacrylate to New Zealand White
rabbits, the substance is regaded as irritating to the skin.
In an acute eye irritation test according the appraisal of the safety of
chemicals in foods, drugs and cosmetics (1959), 6 New Zealand White
rabbits were tested. No irritation was observed in all animals.
Based on the duration and nature of the ocular effects alone, this test
substance is considered to be "slightly irritating" to the eyes of
rabbits (i.e. conjunctival effects only, and reversible within 72 hr but
not 24 hr).
valid in vivo information available to assess the potential for skin and
eye irritation of methyl methacrylate.
reported erythema and eczematous dermatitis in 18/20 human volunteers to
methyl methacrylate (5% in paraffin or olive oil). Although a clear
distinction between sensitisation and irritation was not made by the
author and the exposure period is far longer than usual in irritation
testing the results suggest that MMA may have the potential for skin
irritation in humans.
results of the reliable studies varied. In the most reliable study
(standardized test protocol according to the Draize test, 0.5 mL of the
unchanged test substance were applied to shaved skin sites of six New
Zealand White rabbits under occlusive conditions for 24 hours), only
slight erythema were observed in 1/6 animals in the 24 h reading; no
further effects were observed. The mean erythema and oedema scores were
0.08 and 0.00 for all animals and readings, respectively (Sterner 1977).
On the other hand, Rohm and Haas (1982) reported moderate skin
irritation after application of 0.5 mL of the test substance to the
rabbit skin under occlusive conditions for 4/24 hours. In an overall
view it is considered that methyl methacrylate possess the potential for
results of the reliable studies produced a clear pattern. In the most
reliable study, 0.1 mL of the unchanged test substance was applied to
the eyes of six New Zealand White rabbits and the treated eyes were not
washed out (Sterner 1978). In the relevant reading period between 24 h
and 72 h after application there were no irritation effects observed on
cornea, iris and conjunctivae (redness and chemosis). The respective
scores were 0.0 for all parametersm and all animals. Slight to moderate
conjunctivae redness, chemosis and discharge was observed in the
readings 1 h to 8 h after application, which were not relevant for
addition, slight, transient effects were described in a study of Rohm &
Haas (1982). Overall it is considered that methyl methacrylate possess
the potential for, at most, slight irritation effects on the rabbit eye.
of the respiratory tract
irritation reactions have been observed after short-term peak exposures
to humans at concentration levels exceeding 100 ppm (Coleman, 1963,
Roehm 1994). No damage to olfactory function was reported in a
cross-sectional smell test in workers exposed to MMA up to 50 ppm during
the past 6 years and up to 100 ppm the time before (mean duration of
exposure 9.6 years) (Muttray et al., 1997). No effects were seen after
single exposures to 50 ppm in a study with human volunteers
investigating changes in cytokine levels indicative of subclinical,
irritating effects (Muttray et al., 2007)
results of the reliable animal studies varied between slight and
moderate, reversible irritation effects on the rabbit skin. There are
also indications of irritation in human patch tests with prolonged
exposure. Hence, methyl methacrylate is classified as skin irritation
Cat. 2 according to Regulation
(EC) 1272/2008 requirements and UN-GHS
considered that methyl methacrylate possess the potential for maximum
slight irritation effects on the rabbit eye, which were below the
criteria for classification according to Regulation
(EC) 1272/2008 requirements.
results of studies in humans and animals methyl methacrylate has to be
classified as irritant to the respiratory tract according to Regulation
(EC) 1272/2008 requirementsand
UN-GHS criteria, respectively).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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