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EC number: 201-297-1
CAS number: 80-62-6
Mean measured concentrations (± SD) within the chambers for the 0, 100, 300, 1200 and 2000 ppm groups were 98.8 (±3.4), 304.4 (±9.1), 1178.1 (±69.1) and 2028.2 (±107.3) ppm, respectively.
In a developmental toxicity study (1991) acc. OECD 414 by
inhalation on CRl: CD Br rats pregnant rats were exposed to methyl
methacrylate at concentrations of 0 (control), 99, 304, 1178 and 2028
ppm on days 6-15 of gestation. A maternal no observed level was not
demonstrated since losses in maternal body weight or decreases in
maternal body weight gain and decreases in maternal feed consumption
were noted at all exposure levels tested. No embryo or fetal toxicity
was evodent and no increase in the incidence of malformations or
variations was noted at exposure levels up to and including 2028 ppm.
Therefore toxicity to the conceptus was not evident even at expsoure
levels that resulted in overt maternal toxicity.
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