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Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: personal communication of worker health observations
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Assessment of observations regarding the health of exposed workers; Particularly useful, because historical exposures tended to be at least one order of magnitude higher compared to current work practices and therefor this information is relevant to hazard assessment in humans.

Data source

Reference
Reference Type:
other: expert communication
Title:
Letter to the Chairman if the Threshold Limits Committee of ACGIH
Author:
Coleman AL
Year:
1963
Bibliographic source:
-

Materials and methods

Type of study / information:
Letter of the Chief Industrial Hygienist of the Occupational Health Section of the Labour Department of the State of Connecticut to the Chairman of ACGIH regarding workplace experience of MMA.
Endpoint addressed:
respiratory irritation
Principles of method if other than guideline:
Expert judgement
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl methacrylate
EC Number:
201-297-1
EC Name:
Methyl methacrylate
Cas Number:
80-62-6
Molecular formula:
C5H8O2
IUPAC Name:
methyl methacrylate
Test material form:
liquid

Results and discussion

Results:
The author and the members of his team noted a strong, easily detectable smell in areas with concentrations between 32 and 65 ppm, very definite irritation in areas with 170 to 248 ppm and unbearable discomfort in an area with a spot concentration of 2300 ppm. The author and his team concluded that 100 ppm could be tolerated continuously without discomfort.

Applicant's summary and conclusion

Conclusions:
The effects described in this letter are consistent with irritation in the respiratory tract in humans at concentrations exceeding 100 ppm.
Executive summary:

The effects described in this letter are consistent with irritation in the respiratory tract in humans at concentrations exceeding 100 ppm.