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EC number: 201-297-1
CAS number: 80-62-6
A summary of the mortality data for methyl methacrylate is
group (ppm) Male Female
(0) 12/25 9/25
6/7 7/25 7/25
2000 12/25 10/25
No statistical differences were noted in the
mortality of the animals exposed to methyl methacrylate and those in the
control group. A statistically significant decrease in body weight was
observed in the first week for the female rats and in weeks one through
three in the male rats administered 2000 ppm methyl methacrylate. Water
consumption was reduced in the animals from the high-dose group;
however, it was reported that this finding tended to regress towards the
end of the study. Food consumption was not affected by the
administration of methyl methacrylate in the drinking water.
Hematologic values varied within normal ranges in all groups of
rats throughout the study, and urine concentrations of protein and
reducing substances showed no trends that appeared relatable to
Organ to body weight ratios obtained at sacrifice of 2-year
survivors differed from the controls only in significantly increased
kidney ratios in female rats receiving 2000 ppm of methyl methacrylate
(controls 0.0082 ± 0.0019; treated 0.0094 ± 0.0011).
Histopathologic findings showed no abnormalities or lesions, in
kind or incidence, not explicable on the basis of naturally occurring
ones in this strain of rat at this age.
Diet equivalents of the test materials were calculated from the
fluid and food consumption data.
these calculations, corrections were not made for evaporation losses of
the test materials from the drinking water, the orders of magnitude of
which are given under methods described above (maximum 15%). Allowing
for such losses, it would appear that the concentrations of test
materials in the drinking water were equivalent to approximately 10,
100, and 3000 ppm in the diet.
A two years toxicity study was performend in 1964 to study the
tolerance of animals to chronic ingestion of methyl methacrylate.
Twenty-five male and female Wistar rats were administered three
doses of methyl methacrylate in the drinking water for two years
(Borzelleca et al. 1964). Initial doses of 6, 60 or 2000 ppm were
partially raised to 7, 70 and 2000 ppm after 5 months.
A special design was employed to reduce the volatilization and
measurements which showed that the methyl methacrylate concentrations
remained within 15% of the nominal concentration for 72 hours. Body
weight depression was also observed at 2000 ppm but it did not persist
beyond the first few weeks of the study. Significant depression of fluid
consumption was observed at 2000 ppm, although this tended to regress at
the end of the study. Individual observations of depressed food
consumption tended to parallel periods of depressed growth. There were
significantly increased kidney ratios for female rats at 2000 ppm. These
effects were believed to be a consequence of reduced food intake and
reduced body weights, and in the absence of any histopathology, were
considered as not biologically relevant. Therefore the NOAEL is
considered to be >= 2000 ppm, corresponding to 90.3 mg/kg bw/day and
193.8 mg/kg bw/day, for males and females, respectively, on the basis of
treatment specific fluid consumption rates and body weights.
No relevant effects were observed after exposure of rats in
drinking water up to the highest dose tested (2000 ppm, limited by
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