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Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Effect of simplex liquid methyl methacrylate monomer on cells
Author:
Welch A.B.
Year:
1978
Bibliographic source:
J. Biomed. Mat. Res. 12: 775-790 (1978)

Materials and methods

Type of study / information:
other: macrophage inhibition in vitro
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl methacrylate
EC Number:
201-297-1
EC Name:
Methyl methacrylate
Cas Number:
80-62-6
Molecular formula:
C5H8O2
IUPAC Name:
methyl methacrylate
Test material form:
liquid

Results and discussion

Any other information on results incl. tables

The ability of macrophages obtained from the peritoneal cavity of mice to phagocyte Staphylococcus aureus  was inhibited by 0.5% MMA in the culture medium.  Human heparinised blood was incubated with concentrations of 0.5%, 1.25%, and 2.5% MMA for 15 min.  The number of leucocytes was reduced at a concentration of 2.5% MMA, no viable cells
were detected by the trypane blue method, at 1.25% the number of viable leucocytes was reduced to about 50%.  Phagocytic polymorphonuclear neutrophils were damaged to a greater extent than lymphocytes.  Erythrocytes and platelets
were completely lysed at 2.5% MMA.

Applicant's summary and conclusion