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EC number: 201-297-1
CAS number: 80-62-6
Mortality: No difference in survival between treated and untreated
Site / Lesion
Nasal Cavity /
Olfactory sensory epithelium /
Focal or multifocal fibrosis
No histopathological findings other than local findings in the
respiratory tract. Systemic histopathological effects, as for example in
the brain in females particularly at 2000 ppm and above in the
subchronic range finding study (Batelle, 1980), are absent in this 104
Body weight: Mean body weight gain was reduced in females at 500 ppm
resulting in 6 -11% lower body weights after week 73 and in males at
1000 ppm which were 5 -10 % lower than controls after week 81.
There was no treatment-related increase in tumour incidence.
In this104-week study with groups of 50 animals each, male rats
were treated with MMA vapour by whole-body exposure to 500 or 1000 ppm
while female rats were exposed to 250 or 500 ppm. Control animals were
only treated with air.
The primary finding was inflammation of rat nasal cavity as well
as olfactory epithelial degeneration at all exposure levels in male and
female rats. For local effects the LOAEC was 250 ppm in this study while
a NOAEC could not be found.
No other significant histopathological changes were reported in
male and female rats after 104-week exposures to MMA vapour in this
study. Based on this a NOEC for systemic effects of 500 ppm is derived.
Male and female rat body weights were lower at the 1000 ppm
(5-10%) and 500 ppm (6-11%) exposure levels, respectively, presumably
due to reduced food consumption due to nasal irritation and damage of
olfactory epithelium. While food consumption was not recorded in this
study this association is confirmed by two other studies, the
developmental toxicity study with MMA with reduced food consumption and
reduced body weight gain at concentrations higher than 99 ppm (Solomon,
1993) and a subchronic inhalation study with methacrylic acid where
there was also an association of irritative effects in the nose and
reduced food consumption and reduced body weight gain (BASF, 2008).
Consequently, reduced body weight gain, while clearly treatment-related
- is considered to be secondary to the local effects in the nose and not
the result of true systemic toxicity.
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