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EC number: 201-297-1
CAS number: 80-62-6
There are a number of findings which may indicate an effect on the
nervous system. In oral subchronic rat and mice studies (Batelle 1980,
see IUCLID chapter 7.5.3), effects on behaviour (listlessness,
locomotoric activity, learning ability, gait and rear leg function), and
changes in brain chemistry and peripheral nervous system were observed.
Malacia and gliosis of the brain occurred at doses >4 .1 mg/l
(equivalent to >1,000 ppm) in rats which inhaled methyl methacrylate
vapour for 14 weeks.
However, these neurotoxic effects occurred
only at very high concentrations were not seen in the chronic inhalation
studies up to concentrations of 500 ppm and are, hence, not relevant for
While narcotic effects might occur at concentrations approaching acute
lethality, the primary hazard occurring at much lower and more relevant
concentrations is irritancy to the respiratory tract.
Hence, no classification is proposed for neurotoxic effects.
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