Methyl chloroacetate

Carcinogenicity

Administrative data

Endpoint:

carcinogenicity

Remarks:

intraperitoneal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: No guideline and no GLP data. The intraperitoneal route is not relevant and the animals were only administered the substance three times weekly.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1979

Materials and methods

Principles of method if other than guideline:

Groups of 20 mice (10 males and 10 females) were given 3 times weekly i.p. injections of the maximum tolerated dose, one-half of the tolerated dose and either one-forth or one-fifth the maximum tolerated dose. Twenty-four weeks after the first injection, the mice were sacrificed and the lungs were examined.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Methyl chloroacetate

EC Number:

202-501-1

EC Name:

Methyl chloroacetate

Cas Number:

96-34-4

Molecular formula:

C3H5ClO2

IUPAC Name:

methyl 2-chloroacetate

Details on test material:

- Name of test material (as cited in study report): Methyl chloroacetate

Test animals

Species:

mouse

Strain:

Strain A

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: Tricaprylin

Analytical verification of doses or concentrations:

no

Duration of treatment / exposure:

Twenty-four weeks

Frequency of treatment:

3 times weekly

Doses / concentrations

Remarks:

Doses / Concentrations:
0.09, 0.18, 0.36 mmol/kg bw/injection
Basis:
nominal conc.

No. of animals per sex per dose:

10 animals per sex per dose

Control animals:

yes, concurrent vehicle

Results and discussion

Results of examinations

Relevance of carcinogenic effects / potential:

The meaningfulness of ths method is limited. In this carcinogenicity test, the induction of lung tumours occurs wiwth a high incidence in the mouse strain used and is frequently brought about following administration of a carcinogenic substance.

Applicant's summary and conclusion

Conclusions:

Methyl chloroacetate was not tumorigenic by pulmonary adenoma bioassay.

Executive summary:

Groups of 20 mice (10 males and 10 females) were given 3 times a week for 8 weeks i.p. injections of the maximum tolerated dose, one-half of the tolerated dose and either one-forth or one-fifth the maximum tolerated dose (0.36, 0.18 and 0.09 mmol/kg bw, respectively). Twenty-four weeks after the first injection, the mice were sacrificed and the lungs were examined. No increased incidence of lung tumours was found. Methyl chloroacetate was not tumorigenic by pulmonary adenoma bioassay.