Registration Dossier
Registration Dossier
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EC number: 202-501-1 | CAS number: 96-34-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence: Experimental results without analytical monitoring and ECOSAR calculations. Data from the substance methyl monochloroacetate and the analogue ethyl monochloroacetate.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.581 mg/L
Additional information
Experimental results are available from a study conducted in fish with the substance methyl chloroacetate. The LC50 for fish was concluded to be 1.13 mg/l. However, no analytical monitoring was conducted during the study. Therefore, there is no evidence that the concentration of the substance was maintained during the test.
The analogue ethyl chloroacetate which shares the same functional group with methyl chloroacetate, also has comparable values for the relevant molecular properties for the aquatic toxicity endpoint. These properties are:
- a low log Pow value which is 0.94 -1.12 for ethyl chloroacetate and 0.63 for methyl chloroacetate,
- a high water solubility which is 20 g/l at approximately 20 ºC for ethyl chloroacetate and 51.6 g/l for methyl chloroacetate and
- similar molecular weights which are 122.55 for ethyl chloroacetate and 108.52 for methyl chloroacetate.
The analogue ethyl chloroacetate is included in the list of harmonised classifications and labellings and it is classified as Hazardous for the Aquatic Environment, Acute Category 1. ECOSAR calculations were conducted for both methyl chloroacetate and the analogue ethyl chloroacetate. The outcome of these calculations shows that the LC50 values for fish for both substances is below 1 mg/l. These results support the classification for methyl chloroacetate as Hazardous for the Aquatic Environment, Acute Category 1.
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