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EC number: 202-501-1 | CAS number: 96-34-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl chloroacetate
- EC Number:
- 202-501-1
- EC Name:
- Methyl chloroacetate
- Cas Number:
- 96-34-4
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- methyl 2-chloroacetate
- Details on test material:
- - Name of test material (as cited in study report): monochloressigsäuremethylester
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Kastengrund, SPF-Zucht
- Age at study initiation: 8-10 months
- Weight at study initiation: males: 203-225 g; females: 191-220 g
- Diet (e.g. ad libitum): Altromin 1324 (Altromin-GmbH, Lage/Lippe), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 ºC
- Humidity (%): 50 ± 20%
- Photoperiod: 12 hours light/12 hours dark
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The test substance was applied continuously with a permanent drip apparatus and was evaporated at 130 ºC.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 90, 210, 315 and 385 ppm
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: two daily observations and body weights were recorded at 0, 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, necropsy.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 210 - 315 ppm
- Exp. duration:
- 4 h
- Mortality:
- Mortality was observed at 315 and 385 ppm.
- Clinical signs:
- other: 90 ppm: squatting position, uncoordinated walk, irregular and laboured respiration. At the higher dose groups: prone position, reeling walk, noisy respiration, hyporeflexia, corneal opacity and cyanose.
- Gross pathology:
- Dark red dyed lungs. While cutting the lung, foamy liquid escaped in the majority of the animals. The intestine mucous membrane was red and was filled with foamy liquid.
Any other information on results incl. tables
Table 7.2.2 -2: Mortality
Concentration (ppm) |
Mortality |
|
Males |
Females |
|
90 |
0/5 |
0/5 |
210 |
0/5 |
0/5 |
315 |
3/5 |
4/5 |
385 |
5/5 |
5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4-h LC50 in rats was determined to be between 210 and 315 ppm (638 and 957 mg/m3).
- Executive summary:
An acute inhalation toxicity study was carried out with the substance methyl chloroacetate. Groups of five Wistar rats per sex were exposed at 90, 210, 315 and 385 ppm for 4 hours. The 4-h LC50 in rats was determined to be between 210 and 315 ppm (638 and 957 mg/m3).
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