Registration Dossier
Registration Dossier
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EC number: 202-501-1 | CAS number: 96-34-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Mutagenicity in vitro (Ames test): The test compound did not cause a significant increase in the number of revertant colonies with any of the tester strains neither in the absence nor presence of S9-mix. It is concluded that the test substance is not mutagenic in this bacterial test system neither in the absence nor in the presence of metabolic activation.
Chromosome aberration in vivo (micronucleus assay: The incidence of micronucleated polychromatic erythrocytes in the treated animals was within the normal range of the negative control. The number of normochromatic erythrocytes containing micronuclei was not increased. The ratio of polychromatic/normochromatic erythrocytes in both male and female animals remained unaffected by the treatment. It can be stated that, under the conditions described, administration of methyl chloroacetate did not lead to a substantial increase of micronucleated polychromatic erythrocytes. It is concluded that the test substance is not mutagenic in the micronucleus test.
Short description of key information:
Experimental results in vitro (Test Ames, OECD 471) and experimental results in vivo (micronucleus test, OECD 474).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results from the in vitro mutagenicity assay (Ames test) and the results from the in vivo chromosome aberration study (micronucleus assay), the substance is not classified for genetic toxicity.
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