Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Weight of evidence: experimental results, QSAR prediction and read-across. 

Key value for chemical safety assessment

Additional information

Experimental results are available from a study conducted in Daphnia with the substance methyl chloroacetate. The EC50 for Daphnia was concluded to be 5.5 mg/l. However, no analytical monitoring was conducted during the study. Therefore, there is no evidence that the concentration of the substance was maintained during the test. A QSAR prediction conducted with the Multicase model and reported in the Danish EPA database, provides a 48 -h LC50 for methyl chloroacetate of 1.66 mg/l. The data used in the model come from an EC50 for the analogue ethyl chloroacetate which is reported in a publication with a value of 1.6 mg/l. Using the read-across approach based on the analogue ethyl chloroacetate, an EC50 value of 1.42 mg/l is calculated for methyl chloroacetate on Daphnia magna.