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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: read-across from in vivo study with an analogue
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue ethyl chloroacetate which shares the same functional group with methyl chloroacetate, also has comparable values for the relevant molecular properties for the skin irritation endpoint.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from in vivo study with the analogue ethyl chloroacetate
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Based on the experimental results obtained with the analogue ethyl chloroacetate (reported under the endpoint record 07.03.01_02), which is considered to be irritant, and applying the read-across approach, the substance methyl chloroacetate is also considered as irritant to the skin.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the experimental results obtained with the analogue ethyl chloroacetate (reported under the endpoint record 07.03.01_02), which is considered to be irritant, and applying the read-across approach, the substance methyl chloroacetate is also considered as irritant to the skin.
Executive summary:

Based on the experimental results obtained with the analogue ethyl chloroacetate (reported under the endpoint record 07.03.01_02), which is considered to be irritant, and applying the read-across approach, the substance methyl chloroacetate is also considered as irritant to the skin.