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EC number: 202-501-1 | CAS number: 96-34-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No guideline was followed and no GLP. However, the test method is similar to OECD 401.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- No guideline was followed but the test method was similar to OECD 401.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl chloroacetate
- EC Number:
- 202-501-1
- EC Name:
- Methyl chloroacetate
- Cas Number:
- 96-34-4
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- methyl 2-chloroacetate
- Details on test material:
- - Name of test material (as cited in study report): monochloressigsäuremethylester
- Physical state: colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 219 ± 24.69 g
- Diet (e.g. ad libitum): Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.5 g substance/100 ml vehicle - Doses:
- 50, 80, 100, 125, 200 and 315 mg/kg bw
- No. of animals per sex per dose:
- 10 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: body weight was recorded at 0, 7 and 14 days
- Other examinations performed: clinical signs, necropsy. - Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 107 mg/kg bw
- 95% CL:
- 97.2 - 121
- Mortality:
- Mortality was observed at 100, 125, 200 and 315 mg/kg bw.
- Clinical signs:
- other: Passivity, disturbances of equilibrium, prone position, piloerection, diarrhea, laboured respiration.
- Gross pathology:
- Liver, spleen and kidneys deep brown coloured and strongly supplied with blood, red ovaries.
Any other information on results incl. tables
Table 7.2.1 -1: Mortality
Dose (mg/kg bw) |
Mortality |
50 |
0/10 |
80 |
0/10 |
100 |
4/10 |
125 |
8/10 |
200 |
10/10 |
315 |
10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 (females) was 107 mg/kg bw with a 95% confidence interval between 97.2 and 121 mg/kg bw.
- Executive summary:
The test substance methyl chloroacetate was administered to groups of female Wistar rats by oral gavage at the doses of 50, 80, 100, 125, 200 and 315 mg/kg body weight. Animals were subjected to daily observations and weekly determinations of body weight. Macroscopic examinations were performed on the animals found dead. Mortality was observed at 100, 125, 200 and 315 mg/kg bw. The oral LD50 was 107 mg/kg bw with a 95% confidence interval between 97.2 and 121 mg/kg bw.
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