Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Additional information

There are no reproductive or developmental toxicity studies of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate available. Since inhaled alpha,alpha,alpha-trifluoro-3-tolyl isocyanate vapour will react primarily with lung tissue so that other systemic organ systems or tissues would be affected only at exposure concentrations that produce sufficient lung toxicity. But the propensity of talpha,alpha,alpha-trifluoro-3-tolyl isocyanate to cause lung effects consequently led to secondary effects such as hypoxia that could influence developmental endpoints. Therefore it is not expected to yield useful information from a reproductive or developmental toxicity study of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate vapor inhalation. Thus reproductive toxicity cannot be excluded, but it seems to be unlikely at non irritant alpha,alpha,alpha-trifluoro-3-tolyl isocyanate exposure concentrations.


Short description of key information:
no data

Effects on developmental toxicity

Description of key information
no data
Additional information

There are no reproductive or developmental toxicity studies of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate available. Since inhaled alpha,alpha,alpha-trifluoro-3-tolyl isocyanate vapour will react primarily with lung tissue so that other systemic organ systems or tissues would be affected only at exposure concentrations that produce sufficient lung toxicity. But the propensity of talpha,alpha,alpha-trifluoro-3-tolyl isocyanate to cause lung effects consequently led to secondary effects such as hypoxia that could influence developmental endpoints. Therefore it is not expected to yield useful information from a reproductive or developmental toxicity study of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate vapor inhalation. Thus reproductive toxicity cannot be excluded, but it seems to be unlikely at non irritant alpha,alpha,alpha-trifluoro-3-tolyl isocyanate exposure concentrations.

Justification for classification or non-classification