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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only abstract available; original reference in Russian

Data source

Reference
Reference Type:
publication
Title:
Data to substantiate of the maximum permissible level of m-trifluoromethylphenyl isocyanate and butyl isocyanate in the air of work areas
Author:
Gurova AI, Alekseeva NP, Gorlova OE, Chernyshova RA
Year:
1976
Bibliographic source:
Gig. Tr. Pro. Zabol 3, 53-55, cited from English abstract.

Materials and methods

Principles of method if other than guideline:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Test substance: m-trifluormethylphenyl isocyanate, no data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Remarks on MMAD:
MMAD / GSD: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 months
Frequency of treatment:
periodic (no furher data)
Doses / concentrations
Remarks:
Doses / Concentrations:
1.3, 6.1 and 11.2 mg/m³
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: 3 months

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Histopathological findings: neoplastic:
not specified

Effect levels

Dose descriptor:
other: functional and histological  changes in lungs, liver, kidneys, heart, and brain
Effect level:
11.2 mg/m³ air
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain;

at 1.3 mg/m³ the test substance is nontoxic for rats. All symptoms of poisoning disappear within 3 months after the

experiments are ceased.

Applicant's summary and conclusion

Executive summary:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³.

At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain;

at 1.3 mg/m³ the test substance is nontoxic for rats and mice. All symptoms of poisoning disappear within 3 months after the experiments are ceased.