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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and well documented

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974
Reference Type:
secondary source
Title:
Unnamed
Year:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Six groups of 10 female young adult Wister rats (avarage weight 88 g) each reveived per gavage a single dose of 2500, 4000, 5000, 6300, 8000 or 100000 mg/kg bw m-trifluoromethylphenylisocyanate. The animals were observed for mortality, weight and clinical signs through day 14. a necropsy was performed on animals during the post-observation time.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Test substance: Hoechst substance 99.47 % purity

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesam oil
Doses:
2500, 4000, 5000, 6300, 8000 or 100000 mg/kg bw
No. of animals per sex per dose:
10 female rats per dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
6 604 mg/kg bw

Any other information on results incl. tables

Animals which died during tests had a prone position and balance disturbances. Additionally evidence of an inactive behaviour was seen. An increased vascular network of the stomach and intestine was found macroscopically.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Executive summary:

Six groups of 10 female young adult Wister rats (avarage weight 88 g) each reveived per gavage a single dose of 2500, 4000, 5000, 6300, 8000 or 100000 mg/kg bw m-trifluoromethylphenylisocyanate. The animals were observed for mortality, weight and clinical signs through day 14. a necropsy was performed on animals during the post-observation time.

Animals which died during tests had a prone position and balance disturbances. Additionally evidence of an inactive behaviour was seen. An increased vascular network of the bowel and intestine was found macroscopically. LD 50 = 6604 mg/kg bw (rat, female).