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EC number: 206-341-3
CAS number: 329-01-1
In accordance with column 2 of REACH Annex IX, the study does not need to be conducted, as the substance hydrolyses rapidly in water and the metabolite of the substance (m-Trifluormethylanilin, CAS 98-16-8) has a low potential for bioaccumulation (log Kow < 3).
Isocyanates are known to rapidly hydrolyse under the formation of the
corresponding amine as well as solid polyurea compounds *. However, the
insoluble inert polyurea is not assumed to cause environmental hazards
due to the reduced uptake of high molecular mass compounds, whereas the
amine is assumed to be the ecotoxicological relevant species.
Concluding, tests performed using the corresponding amine can equally be
used to assess the ecotoxicological hazards of isocyanates assuming the
complete transfer of the isocyanate into the corresponding amine while
neglecting the formation of a certain fraction ecotoxicological not
active polyurea compounds. An underestimation of environmental hazards
is thus avoided supporting a conservative and thus protective hazard
* Bayer Industry Services (2004). 4-chlorophenyl-isocyanate:
Investigation on Stability in Aqueous Test Solutions. Project No:
200300181. Leverkusen, Germany.
Bayer Industry Services (2003). Isopropylisocyante: Investigation on
Stability in Aqueous Test Solutions. Project No: 200300095. Leverkusen,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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