Registration Dossier
Registration Dossier
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EC number: 206-341-3 | CAS number: 329-01-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: 5 applications
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 974
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.
- GLP compliance:
- no
Test material
- Reference substance name:
- α,α,α-trifluoro-3-tolyl isocyanate
- EC Number:
- 206-341-3
- EC Name:
- α,α,α-trifluoro-3-tolyl isocyanate
- Cas Number:
- 329-01-1
- Molecular formula:
- C8H4F3NO
- IUPAC Name:
- 1-isocyanato-3-(trifluoromethyl)benzene
- Reference substance name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- IUPAC Name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- Details on test material:
- Test substance: Hoechst substance 99.47% purity
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Russian White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 times during 5 days
- Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100%, 10%, 5%, 1%
Basis:
other: concentration of applied test material
- No. of animals per sex per dose:
- 6 animals per concentration
- Control animals:
- other: not required
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.
Applicant's summary and conclusion
- Executive summary:
On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.
Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.
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