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Administrative data

Description of key information

A reliable acute oral oral toxicity study was available for evaluation. Inhalation and dermal toxicity studies were available from secondary sources.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
6 604 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
0.036 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
discriminating dose
210 mg/kg bw

Additional information

In the most reliable study an oral LD50 = 6604 mg/kg bw for rats was determined. The oral studies from Gurova et al., which were only available in Russian a lower LD50 = 975 mg/kg bw was found. For these studies only limited details were availble and therefore the study was disregarded.

In an acute inhalation study a LC50 > 0.036 mg/l was stated. In the study rats were exposed to 0.013, 0.032, 0.054 and 0.19 mg/m³

of the test substance. No effects due to the compound were found at lower doses. Therefore it is assumed that the stated value is a typing error and should be replaced by LC50 > 0.036 mg/m³. LC50 values in the other studies are in the same range or magnitude.

In a MSDS for the acute dermal toxicity a LD50 > 210 mg/kg bw was stated.

Justification for classification or non-classification

Due to the result of the most reliable acute oral toxicity study a classification is not justified.

For the acute inhalation toxicity a classifiacion as T+; R26 (Acute Tox. 1; H 330) and for acute dermal toxicity a classification as Xn, R22 (Acute Tox. 3; H311) is proposed.