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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method B.2 (Acute Toxicity (Inhalation))
Version / remarks:
Cited as Directive 84/449/EEC, B.2
Principles of method if other than guideline:
Rats were exposed for 4 hours to concentrations 0.19, 0.054. 0.032 or 0.012 mg/m³ of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate. The animals were observed for mortality and a necropsy was performed.
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Test substance: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
0.013, 0.032, 0.054, 0.19 mg/m³
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
>= 0.036 mg/L air
Exp. duration:
4 h

Any other information on results incl. tables

Study at 4 doses: 0.19, 0.054, 0.032 and 0.013 mg/m3. All animals died at 0.19 mg/m³,
At 0.054 mg/m³ 9/10 rats (5 male, 4 female) died during the observation period; clinical signs: exaggerated respiratory
movements, lethargy and death over days 5, 6, and 7 of the observation period. At necropsy, areas of lung congestion
and swollen appearance of the lungs.
No effects due to the compound at lower doses.

Applicant's summary and conclusion

Executive summary:

Rats were exposed for 4 hours to concentrations 0.19, 0.054. 0.032 or 0.013 mg/m³ of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate. The animals were observed for mortality and a necropsy was performed. All animals died at 0.19 mg/m³.
At 0.054 mg/m³ 9/10 rats (5 male, 4 female) died during the observation period; clinical signs: exaggerated respiratory
movements, lethargy and death over days 5, 6, and 7 of the observation period. At necropsy, areas of lung congestion
and swollen appearance of the lungs. No effects due to the compound at lower doses.

LC50 >= 0.036 mg/l