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EC number: 247-148-4
CAS number: 25637-99-4
HBCDD was negative for the induction of mutagenicity in the Ames test
(with and without activation), in in vitro genotoxicity assays in
mammalian cells and in in vitro chromosome aberration and in
vivo mouse micronucleus tests. The tests were conducted according to
standardised guidelines and GLP. One study (Helleday et al., 1999) using
an invalidated method of unknown applicability and assigned a
reliability score of 4 reported a positive result (the test substance
resulted in a 1.9 fold recombinogenic response in SPD8 assay compared to
the control). However, the effects were small compared to known
recombinogenic agents and the biological significance of the effects
with regard to the in vivo situation remains unclear.
HBCCD was negative for mutagenicity in the Ames, in vitro
chromosome abberation, in vitro mouse lymphoma and in vivo
mouse micronucleus studies. Therefore the substance does not meet the
criteria for classification according to 67/548/EEC and EC Regulation
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