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EC number: 247-148-4
CAS number: 25637-99-4
The following information is available for the bioaccumulation/bioconcentration endpoint:Drottar, K. R. and Krueger, H. O. (2000). Hexabromocyclododecane (HBCD): A flow-through bioconcetration test with rainbow trout (Oncorhynchus mykiss). Report no.: WIL 439A-111. Report date: 2000-08-10.Veith, G.D., deFoe, D.L. and Bergstedt, B.V. (1979) Measuring and estimating the bioconcentration factor of chemicals in fish. J. Fish. Res. Board Can. 36: 1040-1048.Zeger, B. N., Mets, A., van Bommel, R., Minkenberg, C., Hamers, T., Kamstra, J. H., Learmont, J. A., Vasquez, B. S., Pierce, G., Ried, B., Patterson, T., Rogan, E., Murphy, S., Addink, M., Hartmann, M. G., Smeenk, C., Dabin, W., Ridoux, V., González, A. F., López, A., Jauniaux, T. and Boon, J. P. (2004). Stereo-isomer specific bioaccumulation of hexabromocyclododecane (HBCD) in marine mammals. Third International Workshop on Brominated Flameretardants (BFR) (2004) pp.411-414.Drottar and Krueger (2000) was selected as the key study based upon reliability and depth of reporting. The study was conducted according to EPA OPPTS 850.1730 and OECD Guideline 305, no deviations from these guidelines are reported in the study report. The study was conducted according to GLP standards and with full reporting of methodologies and results. Drottar and Krueger (2000) was therefore allocated the reliability score of 1 according to the criteria of Klimisch et al. (1997).Veith et al (1979) was performed in line with sound scientific principles but not in line with GLP. The study was therefore allocated a reliability score of 2 according to the criteria of Klimisch (1997).Zeger et al. (2004) was conducted as a field study and no test guideline was available. No details of GLP conditions were given for analysis of samples and insufficient information was provided on methodologies. The study was therefore allocated a reliability score of 4 according to the criteria of Klimisch (1997).
Drottar (2000) was conducted on Oncorhynchus mykiss (rainbow
trout) at test concentrations of 0.34 and 3.4 µg/l (nominal) (0.18 and
1.8 µg/l measured) according to recognised testing guidelines. The
exposure period was 35 days, test solutions were prepared by
continuous-flow diluter and the study was conducted as a flow-through
test. A depuration period of 35 days followed the exposure period.
The following BCF values were calculated for the study:
Depuration times were calculated as follows:
body (dry weight) BCF value was chosen as the key value for this
endpoint as it most adequately describes the likely bioconcentration of
the substance into fish, and provides an indication of the possible
exposure to higher predators through prey animals. As the 1.8 µg/l group
attained a steady-state within the study period it was considered to be
more reliable than the 0.18 µg/l group which did not attain a
Veith et al. (1979) determined the BCF of HBCDD in fathead minnow
following exposure of the animals to 6.2 µg HBCDD/L for 32 days at 25 ±
0.5ºC. Out of a exposed population of 30 fish, five were removed for
analysis after 2, 4, 8, 16 and 32 days exposure. The steady-state BCF
was determined to be 18100 (log BCF 4.26).
Zeger et al. (2004) was conducted as a field study on beached Phocena
phocena (Harbour porpoises) and Common dolphins (Delphinus delphis).
Beached animals were sampled for concentrations of HBCDD in individual
tissues. The substance was found to be metabolised in marine mammals and
may accumulate to "a certain degree" in lipid-rich tissues. These
findings support the results of the key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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