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EC number: 247-148-4
CAS number: 25637-99-4
The following information is available for this endpoint:Drottar, K. R. and Krueger, H. O. (1998). Hexabromocyclododecane (HBCD): A flow-through life-cycle toxicity test with the cladoceran (Daphnia magna). Report no.: 439A-108. Report date: 1998-04-30.Drottar and Krueger (1998) is the key study for this endpoint. This study was conducted in accordance with recognised testing guidelines and under conditions of GLP and was allocated a reliability score of 1 according to the criteria set out by Klimisch et al. (1997).
21 day EC50
for survival and reproduction in Daphnia
was greater than the highest dose tested (13.6 µg/L nominal; 11 µg/L
measured, gamma diastereomer). This is equivalent to greater 17.2 µg of
the commercial HBCDD product per litre
of water. The 21 day NOEC in Daphnia for survival, reproduction and
growth was 3.1 µg/L (measured). This value is approximately
equal to the water solubility of the gamma diastereomer which typically
makes up ≥ 80% of the commercial product and on which the
test concentrations were based. Thus the 21 day NOEC is that of the
gamma diastereomer rather than the commercial HBCDD product. Using the
composition of the test substance, the 21 day NOEC is equivalent to 3.9
µg/L of the commercial product. The Maximum Accepted Toxicant
Concentration was calculated to be 4.2 µg/L based on the measured
concentration of the gamma diastereomer (3.1 µg/L) or 5.3 µg/L for the
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